Vaccination elicits HIV broadly neutralizing antibodies in primates

Author information

Author notes

Jeong Hyun Lee

Present address: Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA

These authors contributed equally: Jon M. Steichen, Patrick J. Madden

Authors and Affiliations

Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA

Jon M. Steichen, Oleksandr Kalyuzhniy, Alessia Liguori, Christopher A. Cottrell, Krystal M. Ma, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps, Danny Lu, Diana Goodwin, Ryan Tingle, Yumiko Adachi, Nushin Alavi, Jenny Tran, Daniel L. V. Bader, Grace Pixton, Agnes Walsh, Mariane B. Melo, Torben Schiffner, Dennis R. Burton, Darrell J. Irvine, James C. Paulson & William R. Schief

IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA

Jon M. Steichen, Claudia T. Flynn, Swastik Phulera, Oleksandr Kalyuzhniy, Alessia Liguori, Carolyne Kifude, Leigh M. Sewall, Christopher A. Cottrell, Krystal M. Ma, Katherine McKenney, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps, Danny Lu, Diana Goodwin, Ryan Tingle, Yumiko Adachi, Nushin Alavi, Jenny Tran, Andy S. Tran, Daniel L. V. Bader, Hannah Voic, Xiaoya Zhou, Grace Pixton, Torben Schiffner, Dennis R. Burton, Gabriel Ozorowski, Andrew B. Ward & William R. Schief

Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA

Jon M. Steichen, Patrick J. Madden, Claudia T. Flynn, Swastik Phulera, Monolina Shil, Oleksandr Kalyuzhniy, Alessia Liguori, Carolyne Kifude, Leigh M. Sewall, Christopher A. Cottrell, Krystal M. Ma, Sabyasachi Baboo, Katherine McKenney, Ivy Phung, Parham Ramezani-Rad, Ester Marina-Zárate, Brian Freeman, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps, Danny Lu, Diana Goodwin, Ryan Tingle, Yumiko Adachi, Nushin Alavi, Jenny Tran, Andy S. Tran, Daniel L. V. Bader, Hannah Voic, Xiaoya Zhou, Grace Pixton, Torben Schiffner, Dennis R. Burton, Darrell J. Irvine, James C. Paulson, John R. Yates III, Gabriel Ozorowski, Andrew B. Ward, Shane Crotty & William R. Schief

Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA

Patrick J. Madden, Monolina Shil, Ivy Phung, Parham Ramezani-Rad, Ester Marina-Zárate, Brian Freeman & Shane Crotty

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA

Swastik Phulera, Leigh M. Sewall, Sabyasachi Baboo, Jolene K. Diedrich, Andy S. Tran, Daniel L. V. Bader, John R. Yates III, Gabriel Ozorowski & Andrew B. Ward

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA

Allan C. deCamp

Emory National Primate Research Center and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA

Diane G. Carnathan, Alyne Nascimento, Catherine Sovie & Guido Silvestri

The Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA, USA

Zhenfei Xie & Facundo D. Batista

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

Facundo D. Batista

Howard Hughes Medical Institute, Chevy Chase, MD, USA

Darrell J. Irvine

Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA

Shane Crotty

Moderna, Inc., Cambridge, MA, USA

William R. Schief

Authors

Jon M. Steichen

Patrick J. Madden

Claudia T. Flynn

Swastik Phulera

Monolina Shil

Oleksandr Kalyuzhniy

Alessia Liguori

Carolyne Kifude

Leigh M. Sewall

Christopher A. Cottrell

Krystal M. Ma

Sabyasachi Baboo

Jolene K. Diedrich

Katherine McKenney

Allan C. deCamp

Diane G. Carnathan

Ivy Phung

Parham Ramezani-Rad

Ester Marina-Zárate

Brian Freeman

Zhenfei Xie

Jeong Hyun Lee

Troy Sincomb

Nicole Phelps

Danny Lu

Diana Goodwin

Ryan Tingle

Yumiko Adachi

Nushin Alavi

Jenny Tran

Andy S. Tran

Alyne Nascimento

Catherine Sovie

Daniel L. V. Bader

Hannah Voic

Xiaoya Zhou

Grace Pixton

Agnes Walsh

Mariane B. Melo

Torben Schiffner

Facundo D. Batista

Dennis R. Burton

Darrell J. Irvine

James C. Paulson

John R. Yates III

Gabriel Ozorowski

Andrew B. Ward

Guido Silvestri

Shane Crotty

William R. Schief

Corresponding authors

Correspondence to

Shane Crotty or William R. Schief.

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Cite this article

Steichen, J.M., Madden, P.J., Flynn, C.T. et al. Vaccination elicits HIV broadly neutralizing antibodies in primates.

Nature (2026). https://doi.org/10.1038/s41586-026-10837-5

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Received: 12 December 2025

Accepted: 23 June 2026

Published: 30 June 2026

DOI: https://doi.org/10.1038/s41586-026-10837-5