Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer

Retraction to: Nature https://doi.org/10.1038/s41586-025-09727-z Published online 26 November 2025

The Editors have retracted this article at the Authors’ request. After publication, concerns were raised regarding the tumour burden in some mice in the control arms of the experiments presented in Fig. 4b (NPPO1-NE, NPPO-4, NPPO-6, and MSKPCa10 grafts) and Fig. 5j (WCM1262 grafts). The authors have shared the underlying tumour measurement and mouse bodyweight data, which confirmed that animal welfare protocols were breached. An investigation by the Institutional Animal Care and Use Committee at Columbia University Irving Medical Center found that these experiments were not compliant with protocol endpoints. The authors regret this failure to adhere to the highest standards of animal experimentation. No other experimental data or analyses have been affected by the issues underlying the investigation or retraction.

Jia Li does not agree with this retraction. All other authors agree with this retraction.

Author information

Author notes

Xiao Chen

Present address: Marine College, Shandong University, Weihai, China

Min Zou

Present address: Arvinas, New Haven, CT, USA

Tania Pannellini

Present address: Haematopathology Division, IEO European Institute of Oncology, Milan, Italy

These authors contributed equally: Jia J. Li, Alessandro Vasciaveo

Authors and Affiliations

Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Jia J. Li, Cory Abate-Shen, Andrea Califano & Michael M. Shen

Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Jia J. Li, Alessandro Vasciaveo, Cory Abate-Shen, Andrea Califano & Michael M. Shen

Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Jia J. Li, Dimitris Karagiannis, Kristjan H. Gretarsson, Xiao Chen, Xinjing Xu, Chao Lu & Michael M. Shen

Department of Urology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Jia J. Li, Cory Abate-Shen & Michael M. Shen

Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Jia J. Li, Alessandro Vasciaveo, Dimitris Karagiannis, Kristjan H. Gretarsson, Xiao Chen, Ziv Frankenstein, Min Zou, Xinjing Xu, Kevin Gardner, Cory Abate-Shen, Andrea Califano, Chao Lu & Michael M. Shen

Center for Data Science and Artificial Intelligence, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

Alessandro Vasciaveo & Gabriel M. Aizenman

Center for Therapeutics Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

Alessandro Vasciaveo & Gabriel M. Aizenman

Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA

Alessandro Vasciaveo & Gabriel M. Aizenman

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Zhen Sun, Yu Chen & Charles L. Sawyers

Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Ouathek Ouerfelli & Guangli Yang

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA

Fabio Socciarelli, Tania Pannellini, Brian D. Robinson & Massimo Loda

Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Ziv Frankenstein, Kevin Gardner & Cory Abate-Shen

Department of Biology, Stanford University, Stanford, CA, USA

Hanyang Dong & Or Gozani

Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Min Zou & Cory Abate-Shen

Division of Clinical Studies, The Institute of Cancer Research, London, UK

Wei Yuan & Johann de Bono

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

Himisha Beltran

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Yu Chen

Department of Biomedical Research, Bern Center for Precision Medicine, University of Bern, Bern, Switzerland

Mark A. Rubin

Nuffield Department of Surgical Sciences, Lincoln College, University of Oxford, Oxford, UK

Massimo Loda

Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA

Charles L. Sawyers

Department of Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Andrea Califano

Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

Andrea Califano

Chan Zuckerberg Biohub, New York, NY, USA

Andrea Califano

Authors

Jia J. Li

Alessandro Vasciaveo

Dimitris Karagiannis

Zhen Sun

Xiao Chen

Ouathek Ouerfelli

Fabio Socciarelli

Ziv Frankenstein

Hanyang Dong

Min Zou

Wei Yuan

Guangli Yang

Gabriel M. Aizenman

Tania Pannellini

Xinjing Xu

Himisha Beltran

Yu Chen

Kevin Gardner

Brian D. Robinson

Johann de Bono

Or Gozani

Cory Abate-Shen

Mark A. Rubin

Massimo Loda

Charles L. Sawyers

Andrea Califano

Chao Lu

Michael M. Shen

Corresponding authors

Correspondence to

Chao Lu or Michael M. Shen.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

About this article

Cite this article

Li, J.J., Vasciaveo, A., Karagiannis, D. et al. Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer.

Nature (2026). https://doi.org/10.1038/s41586-026-10816-w

Download citation

Published: 30 June 2026

Version of record: 30 June 2026

DOI: https://doi.org/10.1038/s41586-026-10816-w