
Rees-Zammit, who returned to the wing after starting all Six Nations matches at full-back, swaps roles with Mee, with Wales hoping the Bristol back can have a major impact as a replacement.
After starting Tandy's first seven games in charge, fly-half Edwards was dropped for the Six Nations match against Scotland in Cardiff in February.
Costelow impressed before the Scarlets fly-half picked up an injury, allowing Edwards to return for the final two matches against Ireland and Italy.
He responded with an impressive 16-point performance against the Azzurri as Wales ended a three-year Six Nations losing streak.
However, Edwards endured a difficult afternoon against Fiji last Saturday, while Costelow proved an assured second-half presence as a replacement.
With Edwards dropping out of the squad, centre Joe Hawkins will provide fly-half cover.
Scarlets provide five of the seven Wales backs selected, with Mee and Costelow joined by centre pair Hawkins and Eddie James along with full-back Blair Murray.
James, who played for England Under-20s but was born in Pembrokeshire and raised in Cardiff, could win his first cap after a breakthrough season with Prem runners-up Exeter.
The 21-year-old was named in the Wales squad for the first time this summer and is set to be given his opportunity.
"Kane is an exciting player," said Tandy.
"He's so powerful and quick. The way he's come into the environment and just jumped straight in shows he hasn't been tentative in anything he does.
"He creates a big energy in how he goes about his work, he's super diligent around everything, taking on the detail. So I'm excited to see Kane get his first cap on the weekend."
Elias, 31, has forced his way back into the Wales reckoning and his 50th cap would be a reward for his resilience and fine form during the past 12 months.
"Ryan's story is an incredible one," said Tandy.
"He's an outstanding leader and person and he's really added value to our group.
"It's an unbelievable achievement to get 50 caps and an honour that's deserved."
Argentina: S Carreras; Delguy, Cinti, Piccardo, M Carreras; Albornoz, Garcia; Wenger, Montoya (capt), Rapetti, Petti, Alemanno, Grondona, Kremer, Oviedo.
Replacements: Ruiz, Vivas, Coria Marchetti, Molina, Matera, Benitez Cruz, Moroni, Ignacio.
Wales: Murray; Mee, James, Hawkins, Adams; Costelow, Tomos Williams; Carre, Lake (capt), Lewis, Carter, Beard, Botham, Morgan, Wainwright.
Replacements: Elias, N Smith, Warren, Teddy Williams, James, Hardy, Llewellyn, Rees-Zammit.
View original source — BBC Sport ↗
